RNA and protein synthesis is required for Ancylostoma caninum larval activation
نویسندگان
چکیده
منابع مشابه
Anticoagulant repertoire of the hookworm Ancylostoma caninum.
Hookworms are hematophagous nematodes that infect a wide range of mammalian hosts, including humans. There has been speculation for nearly a century as to the identity of the anticoagulant substances) used by these organisms to subvert host hemostasis. Using molecular cloning, we describe a family of potent small protein (75-84 amino acids) anticoagulants from the hookworm Ancylostoma caninum t...
متن کاملToxocara canis Ancylostoma caninum, Echinococcus granulosus etc. T. canis A. caninum and A. braziliense
Parasitic diseases account for important health hazard in human beings and animals around the globe including India [1]. India, as a tropical country, has a wide range of climatic zones, which make it vulnerable for a diverse range of parasites of medical and veterinary importance, whose transmission and geographical distribution are closely linked to regional temperature, rainfall and humidity...
متن کاملThe Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development.
DDX11 was recently identified as a cause of Warsaw breakage syndrome (WABS). However, the functional mechanism of DDX11 and the contribution of clinically described mutations to the pathogenesis of WABS are elusive. Here, we show that DDX11 is a novel nucleolar protein that preferentially binds to hypomethylated active ribosomal DNA (rDNA) gene loci, where it interacts with upstream binding fac...
متن کاملApparent contact dermatitis caused by Ancylostoma caninum: a case report.
Ancylostomum caninum larvae cause damage to the host at the point of entry through the skin leaving a wound vulnerable to secondary infections. As the larvae migrate through the skin an inflammatory response, dermatitis, is often stimulated which can be exacerbated in hosts which give hypersensitive responses. We assessed a 44-year-old man with contact dermatitis diagnosed as nickel allergy but...
متن کاملMitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.
Nod-like receptor family, pyrin domain-containing 3 (NLRP3), is involved in the early stages of the inflammatory response by sensing cellular damage or distress due to viral or bacterial infection. Activation of NLRP3 triggers its assembly into a multimolecular protein complex, termed "NLRP3 inflammasome." This event leads to the activation of the downstream molecule caspase-1 that cleaves the ...
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ژورنال
عنوان ژورنال: Veterinary Parasitology
سال: 2011
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2011.01.062